Players can equip one of three active skills at the start of a match, but passive skills are always enabled. You take control of one of the members of Wolfpack, each with distinct active and passive abilities. Operation Raccoon City is structured much like a team-based military shooter, not unlike Slant Six's previous S.O.C.O.M titles. Fans won't get a lot of new info here, as this is just a trip back to some familiar locations to face some familiar bad guys. It's a plot that mostly exists as an excuse to visit memorable Resident Evil locations. Later, Wolfpack is sent back to 'clean up' Umbrella's messes, including eliminating any witnesses who can trace the incident back to Umbrella. Die-hard fans will recognize this as the start of the entire Raccoon City disaster. The story begins when they, along with fan favorite HUNK, are tasked with stealing the G-Virus from William Birkin. You follow the Wolfpack, a group of specialized mercenaries working for the evil Umbrella Corporation. Resident Evil: Operation Raccoon City is a combination untold story and 'what if?' alternate timeline. An initial small outbreak at the Spencer Mansion was followed by a city-wide outbreak from which Leon Scott Kennedy, Claire Redfield and Jill Valentine had to escape.

The Raccoon City Outbreak was the setting for the first three Resident Evil titles.